Title : Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells.

Pub. Date : 2010 Jul

PMID : 20143408






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines released by oxygen-sensitive cells in response to hypoxic conditions. Oxygen tyrosine hydroxylase Rattus norvegicus
2 Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines released by oxygen-sensitive cells in response to hypoxic conditions. Oxygen tyrosine hydroxylase Rattus norvegicus
3 These results indicate that, under hypoxic conditions, TH (a key factor in systemic adaptation to reduced oxygen availability) is not regulated by HIF-1, the primary modulator of the response to hypoxia, but by the adenosine A(2)A receptor-mediated signalling pathway. Oxygen tyrosine hydroxylase Rattus norvegicus