Title : D1 receptors play a major role in the dopamine modulation of mouse ileum contractility.

Pub. Date : 2010 May

PMID : 20138148






3 Functional Relationships(s)
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1 SCH-23390, D1 receptor antagonist, which per se increased basal tone and amplitude of spontaneous contractions, antagonized the responses to dopamine, whilst sulpiride or domperidone, D2 receptor antagonists, were without effects. Dopamine dopamine receptor D1 Mus musculus
2 SKF-38393, D1 receptor agonist, mimicked dopamine-induced effects. Dopamine dopamine receptor D1 Mus musculus
3 In conclusion, mouse ileum is under basal inhibitory control by dopamine, through D1 receptor activation, linked to adenylyl cyclase and activation of apamin-sensitive potassium channels. Dopamine dopamine receptor D1 Mus musculus