Title : Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.

Pub. Date : 2010 Aug

PMID : 20135346






1 Functional Relationships(s)
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1 We show that metformin (but not rapamycin) exposure leads to increased phosphorylation of IRS-1 at Ser(789), a site previously reported to inhibit downstream signaling and to be an AMPK substrate phosphorylated under conditions of cellular energy depletion. Metformin insulin receptor substrate 1 Homo sapiens