PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20135346-5 2010 We show that metformin (but not rapamycin) exposure leads to increased phosphorylation of IRS-1 at Ser(789), a site previously reported to inhibit downstream signaling and to be an AMPK substrate phosphorylated under conditions of cellular energy depletion. Metformin 13-22 insulin receptor substrate 1 Homo sapiens 90-95