Title : Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.

Pub. Date : 2010 Jan

PMID : 20110775






2 Functional Relationships(s)
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1 Further, bortezomib-treated breast cancer cells showed induction of the unfolded protein response, with upregulation of CH OP and GRP78. Bortezomib DNA damage inducible transcript 3 Homo sapiens
2 Knockdown of CH OP and/or BNIP3 expression via RNAi targeting significantly attenuated the death-promoting effects of bortezomib. Bortezomib DNA damage inducible transcript 3 Homo sapiens