Title : Effects of mevastatin on grafted bone in MRL/MpJ mice.

Pub. Date : 2010 Apr

PMID : 20109072






3 Functional Relationships(s)
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1 (3) The expression of bone morphogenetic protein-2 (BMP-2) mRNA and receptor activator of NF-kB ligand (RANKL) mRNA were upregulated in mevastatin-treated bone. mevastatin tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
2 (3) The expression of bone morphogenetic protein-2 (BMP-2) mRNA and receptor activator of NF-kB ligand (RANKL) mRNA were upregulated in mevastatin-treated bone. mevastatin tumor necrosis factor (ligand) superfamily, member 11 Mus musculus
3 These results suggest that the topical infusion of mevastatin increases bone mass of isografted bone by increasing bone turnover and, at least in part, by promoting the expression of BMP-2 and RANKL mRNA. mevastatin tumor necrosis factor (ligand) superfamily, member 11 Mus musculus