Title : 15-Deoxy-Delta-Prostaglandin J(2) Upregulates the Expression of LPS-Induced IL-8/CXCL8 mRNA in Vascular Smooth Muscle Cells from Spontaneously Hypertensive Rats.

Pub. Date : 2009 Apr

PMID : 20107546






2 Functional Relationships(s)
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1 The upregulatory effect of 15d-PGJ(2) in SHR VSMCs was mediated through PPARgamma, and dependent on NF-kappaB activation and ERK phosphorylation. 15d-pgj peroxisome proliferator-activated receptor gamma Rattus norvegicus
2 CONCLUSION: Our results indicate that the upregulatory effect of 15d-PGJ(2) on LPS-induced IL-8/CXCL8 expression in SHR VSMCs is mediated through the PPARgamma and ERK pathway, and may be related to NAD(P)H oxidase activity. 15d-pgj peroxisome proliferator-activated receptor gamma Rattus norvegicus