Title : Release of interleukins 6 and 8 induced by zymosan and mediated by MAP kinase and NF-kappaB signaling pathways in human corneal fibroblasts.

Pub. Date : 2010 Jun

PMID : 20107167






3 Functional Relationships(s)
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1 RESULTS: Zymosan induced the release of IL-6 and IL-8 from corneal fibroblasts without affecting either the release of IL-1beta, IL-12, IP-10, or RANTES or the expression of ICAM-1 or VCAM-1. Zymosan interleukin 6 Homo sapiens
2 The zymosan-induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK, p38, JNK, and NF-kappaB signaling. Zymosan interleukin 6 Homo sapiens
3 CONCLUSIONS: Zymosan induces the release of IL-6 and IL-8 from human corneal fibroblasts in a manner dependent on MAPK and NF-kappaB signaling pathways. Zymosan interleukin 6 Homo sapiens