Pub. Date : 2010 May
PMID : 20106947
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | The objective of this study was to identify the role of Stat3 in chemoresistance induced by nicotine in human bladder cancer cell line, T24 cells. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | We provide evidence for the first time that nicotine strongly activated Stat3, leading to Cyclin D1 overexpression, cell cycle perturbations, and chemoresistance. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | Furthermore, nicotine mobilized Stat3 signaling, resulting in the loss of extracellular signal-regulated protein kinase 1/2 (ERK 1/2) activation and reduced chemosensitivity via nicotinic acetylcholine receptors and beta-adrenoceptors. | Nicotine | signal transducer and activator of transcription 3 | Homo sapiens |