PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20106947-0	2010	Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.	Nicotine	10-18	signal transducer and activator of transcription 3	Homo sapiens	81-86	
20106947-4	2010	The objective of this study was to identify the role of Stat3 in chemoresistance induced by nicotine in human bladder cancer cell line, T24 cells.	Nicotine	92-100	signal transducer and activator of transcription 3	Homo sapiens	56-61	
20106947-8	2010	We provide evidence for the first time that nicotine strongly activated Stat3, leading to Cyclin D1 overexpression, cell cycle perturbations, and chemoresistance.	Nicotine	44-52	signal transducer and activator of transcription 3	Homo sapiens	72-77	
20106947-9	2010	Furthermore, nicotine mobilized Stat3 signaling, resulting in the loss of extracellular signal-regulated protein kinase 1/2 (ERK 1/2) activation and reduced chemosensitivity via nicotinic acetylcholine receptors and beta-adrenoceptors.	Nicotine	13-21	signal transducer and activator of transcription 3	Homo sapiens	32-37