Title : The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization.

Pub. Date : 2010 Jan 27

PMID : 20105315






1 Functional Relationships(s)
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1 Despite caspase activation, the upregulation of the anti-apoptotic bcl-2 family member protein mcl-1 that resulted from nelfinavir treatment stabilized the mitochondrial membrane potential, resulting in primarily mitochondria-independent cell death. Nelfinavir BCL2 apoptosis regulator Homo sapiens