Title : Structure-activity relationships studies in a series of N,N-bis(alkanol)amine aryl esters as P-glycoprotein (Pgp) dependent multidrug resistance (MDR) inhibitors.

Pub. Date : 2010 Feb 25

PMID : 20104851






1 Functional Relationships(s)
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1 Compound 9 shows the most promising properties as it was able to nearly completely reverse Pgp-dependent pirarubicin extrusion at nanomolar doses and increased the cytotoxicity of doxorubicin with a reversal fold (RF) of 19.1 at 3 microM dose. pirarubicin ATP binding cassette subfamily B member 1 Homo sapiens