Title : AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma.

Pub. Date : 2010 Mar 1

PMID : 20101735






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1 RESULTS: We report here that pharmacological inhibition of the MEK/ERK pathway by AZD6244 enhanced the antitumor and antiangiogenic activities of mTOR inhibitor RAPA in both orthotopic and ectopic models of HCC. AZD 6244 mechanistic target of rapamycin kinase Homo sapiens