Title : Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease.

Pub. Date : 2010 May

PMID : 20101004






1 Functional Relationships(s)
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1 It is noteworthy that dosing 12-week-old, asymptomatic hAPP mice over 7 days with pregnenolone-16alpha-carbonitrile to activate the nuclear receptor pregnane X receptor restores P-glycoprotein expression and transport activity in brain capillaries and significantly reduces brain Abeta levels compared with untreated control mice. Pregnenolone Carbonitrile amyloid beta (A4) precursor protein Mus musculus