Pub. Date : 2010 Apr 2
PMID : 20097939
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway. | Sphingolipids | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 2 | The cleavage of sphingoid base phosphates by sphingosine-1-phosphate (S1P) lyase to produce phosphoethanolamine and a fatty aldehyde is the final degradative step in the sphingolipid metabolic pathway. | Sphingolipids | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 3 | Furthermore, the S1P lyase deficiency resulted in changes in the levels of serum and liver lipids not directly within the sphingolipid pathway, including phospholipids, triacyglycerol, diacylglycerol, and cholesterol. | Sphingolipids | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 4 | These results demonstrate that S1P lyase is a key regulator of the levels of multiple sphingolipid substrates and reveal functional links between the sphingolipid metabolic pathway and other lipid metabolic pathways that may be mediated by shared lipid substrates and changes in gene expression programs. | Sphingolipids | sphingosine-1-phosphate receptor 1 | Mus musculus |
| 5 | These results demonstrate that S1P lyase is a key regulator of the levels of multiple sphingolipid substrates and reveal functional links between the sphingolipid metabolic pathway and other lipid metabolic pathways that may be mediated by shared lipid substrates and changes in gene expression programs. | Sphingolipids | sphingosine-1-phosphate receptor 1 | Mus musculus |