Title : Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis.

Pub. Date : 2010 Jun

PMID : 20097879






1 Functional Relationships(s)
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1 The synergistic interaction of resveratrol and TRAIL depends on the intrinsic apoptosis pathway and caspases, since Bcl-2 overexpression and the caspase inhibitor zVAD.fmk inhibit apoptosis, whereas knockdown of SIRT1 by RNA interference has no effect. Resveratrol BCL2 apoptosis regulator Homo sapiens