Title : Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma.

Pub. Date : 2010 Mar

PMID : 20089779






4 Functional Relationships(s)
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1 Dietary CLA ameliorated disease activity, decreased colitis, and prevented adenocarcinoma formation in the PPARgamma-expressing floxed mice but not in the tissue-specific PPARgamma-null mice. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
2 Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but not in the tissue-specific, PPARgamma-null mice. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
3 Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but not in the tissue-specific, PPARgamma-null mice. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus
4 This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPARgamma-dependent mechanism. Linoleic Acids, Conjugated peroxisome proliferator activated receptor gamma Mus musculus