Title : Ras-induced resistance to lapatinib is overcome by MEK inhibition.

Pub. Date : 2010 Mar

PMID : 20088787






1 Functional Relationships(s)
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1 Importantly, we found that resistance to lapatinib due to ras overexpression or to ras V12 is overcome by MEK inhibition with U0126, suggesting a key role for the MEK-Erk pathway in ras-induced resistance. Lapatinib EPH receptor B2 Homo sapiens