Pub. Date : 2009 Dec
PMID : 20082992
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using the PD animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication in mice, we showed that DMT1 expression increased in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress and dopaminergic cell loss. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 2 | A mutation in DMT1 that impairs iron transport protected rodents against parkinsonism-inducing neurotoxins MPTP and 6-hydroxydopamine (6-OHDA). | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |
| 3 | This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD. | Iron | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | Mus musculus |