Title : Iron transport in Parkinson's disease.

Pub. Date : 2009 Dec

PMID : 20082992






3 Functional Relationships(s)
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1 Using the PD animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication in mice, we showed that DMT1 expression increased in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress and dopaminergic cell loss. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
2 A mutation in DMT1 that impairs iron transport protected rodents against parkinsonism-inducing neurotoxins MPTP and 6-hydroxydopamine (6-OHDA). Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus
3 This study supports a critical role for DMT1 in iron-mediated neurodegeneration in PD. Iron solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 Mus musculus