Pub. Date : 2010 Mar 19
PMID : 20080969
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol also lowers Abeta levels in cell lines; however, the underlying mechanism responsible for this effect is largely unknown. | Resveratrol | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | Direct pharmacological and genetic activation of AMPK lowered extracellular Abeta accumulation, whereas AMPK inhibition reduced the effect of resveratrol on Abeta levels. | Resveratrol | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | Furthermore, resveratrol inhibited the AMPK target mTOR (mammalian target of rapamycin) to trigger autophagy and lysosomal degradation of Abeta. | Resveratrol | amyloid beta (A4) precursor protein | Mus musculus |
| 4 | Finally, orally administered resveratrol in mice was detected in the brain where it activated AMPK and reduced cerebral Abeta levels and deposition in the cortex. | Resveratrol | amyloid beta (A4) precursor protein | Mus musculus |