Title : Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition.

Pub. Date : 2010 Jan 12

PMID : 20080742






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PTP desensitization and the ensuing resistance to cell death induced by arachidonic acid or EM20-25 could be ablated by inhibiting ERK with the drug PD98059 or with a selective ERK activation inhibitor peptide. 5-(6-chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diazaanthracen-10-yl)pyrimidine-2,4,6-trione mitogen-activated protein kinase 1 Homo sapiens
2 PTP desensitization and the ensuing resistance to cell death induced by arachidonic acid or EM20-25 could be ablated by inhibiting ERK with the drug PD98059 or with a selective ERK activation inhibitor peptide. 5-(6-chloro-2,4-dioxo-1,3,4,10-tetrahydro-2H-9-oxa-1,3-diazaanthracen-10-yl)pyrimidine-2,4,6-trione mitogen-activated protein kinase 1 Homo sapiens