Title : Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice.

Pub. Date : 2010 Mar

PMID : 20072781






5 Functional Relationships(s)
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1 OBJECTIVE: The aim of this study was to examine the role of nAChRs containing alpha7 or beta2 subunits in ethanol consumption. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 In contrast, mice lacking the alpha7 nAChR receptor subunit consumed significantly less ethanol than wild-type mice but consumed comparable amounts of water, saccharin, and quinine. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 In contrast, mice lacking the alpha7 nAChR receptor subunit consumed significantly less ethanol than wild-type mice but consumed comparable amounts of water, saccharin, and quinine. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 CONCLUSIONS: This study provides evidence that alpha7 nAChRs are involved in ethanol consumption and supports the idea that pharmacological manipulation of nAChRs reduces ethanol intake. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
5 CONCLUSIONS: This study provides evidence that alpha7 nAChRs are involved in ethanol consumption and supports the idea that pharmacological manipulation of nAChRs reduces ethanol intake. Ethanol cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus