Title : The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.

Pub. Date : 2010 May

PMID : 20072121






3 Functional Relationships(s)
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1 The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats. LY 379268 solute carrier family 1 member 2 Rattus norvegicus
2 In this study, we tested the hypothesis that administration of the mGluR2/3 agonist LY379268 blocks the effect of GLT-1 upregulation on PPI of the startle. LY 379268 solute carrier family 1 member 2 Rattus norvegicus
3 We showed that administration of LY379268 (1 mg/kg) prevented PPI alterations associated with GLT-1 upregulation, suggesting that CEF-induced PPI impairment was mGluR2/3 dependent. LY 379268 solute carrier family 1 member 2 Rattus norvegicus