Title : The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms.

Pub. Date : 2010 Mar

PMID : 20071162






1 Functional Relationships(s)
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1 Sorafenib treatment correlated with a downregulation of both FLICE-Inhibitory Protein (FLIP) and myeloid cell leukaemia-1 (Mcl-1), caused by a proteasomal degradation of both proteins. Sorafenib CASP8 and FADD like apoptosis regulator Homo sapiens