Pub. Date : 2010 Mar 12
PMID : 20068038
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of Thr-516 and Ser-520 in the kinase activation loop of MEKK3 is required for lysophosphatidic acid-mediated optimal IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-kappaB) activation. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | MEKK3 serves as a critical intermediate signaling molecule in lysophosphatidic acid-mediated nuclear factor-kappaB (NF-kappaB) activation. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Furthermore, substitution of these two residues with alanine abolished the ability of MEKK3 to mediate lysophosphatidic acid-induced optimal IKKbeta/NF-kappaB activation. | lysophosphatidic acid | nuclear factor kappa B subunit 1 | Homo sapiens |