Pub. Date : 2010 May
PMID : 20060890
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth. | Simvastatin | phosphatase and tensin homolog | Homo sapiens |
| 2 | Importantly, simvastatin markedly prevented binding of NFkappaB to the two canonical recognition elements, NFRE-1 and NFRE-2 present in the PTEN promoter. | Simvastatin | phosphatase and tensin homolog | Homo sapiens |
| 3 | Contrary to the transcriptional suppression of Bcl(XL), simvastatin significantly increased the transcription of PTEN. | Simvastatin | phosphatase and tensin homolog | Homo sapiens |
| 4 | Taken together, our data present a novel bifaceted mechanism where simvastatin acts on a nodal transcription factor NFkappaB, which attenuates the expression of anti-apoptotic Bcl(XL) and simultaneously derepresses the expression of anti-proliferative/proapoptotic tumor suppressor PTEN to prevent breast cancer cell growth. | Simvastatin | phosphatase and tensin homolog | Homo sapiens |