Pub. Date : 2010 Mar
PMID : 20056894
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Green tea catechin EGCG inhibits ileal apical sodium bile acid transporter ASBT. | epigallocatechin gallate | solute carrier family 10 member 2 | Homo sapiens |
| 2 | Our data showed that ASBT activity was significantly decreased by (-)-epigallocatechin-3-gallate (EGCG) but not other green tea catechins. | epigallocatechin gallate | solute carrier family 10 member 2 | Homo sapiens |
| 3 | Our data showed that ASBT activity was significantly decreased by (-)-epigallocatechin-3-gallate (EGCG) but not other green tea catechins. | epigallocatechin gallate | solute carrier family 10 member 2 | Homo sapiens |
| 4 | Concomitant with the decrease in ASBT function, EGCG significantly reduced ASBT pool in the detergent-insoluble fraction, while increasing its presence in the detergent-soluble fraction of plasma membrane. | epigallocatechin gallate | solute carrier family 10 member 2 | Homo sapiens |
| 5 | Furthermore, EGCG decreased the association of ASBT with floating lipid raft fractions of cellular membrane on Optiprep density gradient. | epigallocatechin gallate | solute carrier family 10 member 2 | Homo sapiens |
| 6 | In conclusion, our data demonstrate a novel role of lipid rafts in the modulation of ASBT function by the dietary component EGCG, which may underlie the hypocholesterolemic effects of green tea. | epigallocatechin gallate | solute carrier family 10 member 2 | Homo sapiens |