Pub. Date : 2010 Apr
PMID : 20054526
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Fourteen CML patients were phenotyped for in vivo CYP3A activity using quinine as a probe drug. | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The plasma concentration ratio of quinine and its CYP3A metabolite was used for assessing CYP3A activity. | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | RESULTS: Patients that achieved complete molecular response showed significantly (Mann-Whitney U-test, p=0.013) higher in vivo CYP3A activity (median quinine metabolic ratio = 10.1) than patients achieving partial molecular response (median = 15.9). | Quinine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |