Title : Panicolytic-like effect of BDNF in the rat dorsal periaqueductal grey matter: the role of 5-HT and GABA.

Pub. Date : 2010 Jun

PMID : 20047714






3 Functional Relationships(s)
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1 In this study we investigated the effect of intra-DPAG injection of BDNF in a proposed animal model of panic: the escape response evoked by the electrical stimulation of the same midbrain area. dpag brain-derived neurotrophic factor Rattus norvegicus
2 Bicuculline also blocked the inhibitory effect of BDNF on mean arterial pressure increase caused by electrical stimulation of DPAG. dpag brain-derived neurotrophic factor Rattus norvegicus
3 Therefore, in the DPAG, BDNF-TrkB signalling interacts with the GABAergic system to cause a panicolytic-like effect. dpag brain-derived neurotrophic factor Rattus norvegicus