Pub. Date : 2010 Mar
PMID : 20043958
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Investigating the effect of MG-132 on secretion of the cytokine IL-6 we show that while short-term pretreatment with MG-132 (30min) partially reduced TNFalpha-induced IL-6 via inhibition of IkappaB-alpha degradation and the NF-kappaB pathway, longer-term proteasome inhibition (up to 24h) robustly upregulated MKP-1 and was temporally correlated with repression of p38-mediated IL-6 secretion from ASM cells. | benzyloxycarbonylleucyl-leucyl-leucine aldehyde | mitogen-activated protein kinase 14 | Homo sapiens |