PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20028775-0 2010 The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. Tyrosine 53-62 protein tyrosine kinase 2 beta Homo sapiens 48-52 20028775-4 2010 To address this issue, the role of individual signaling pathways in the phosphorylation of Pyk2 tyrosines 402 and 580 upon TCR activation was assessed in human T cells. Tyrosine 96-105 protein tyrosine kinase 2 beta Homo sapiens 91-95 20028775-5 2010 In contrast to other receptor systems, the TCR-induced phosphorylation of Pyk2 tyrosines 402 and 580 was dependent on the Src family kinases, Fyn or Lck. Tyrosine 79-88 protein tyrosine kinase 2 beta Homo sapiens 74-78 20028775-6 2010 Interestingly, the TCR-mediated phosphorylation of Pyk2 tyrosines 402 and 580 did not require Ca(2+) influx, ZAP-70 activation, actin cytoskeleton rearrangement, or PI3K function. Tyrosine 56-65 protein tyrosine kinase 2 beta Homo sapiens 51-55