Title : A skin permeability model of insulin in the presence of chemical penetration enhancer.

Pub. Date : 2010 Mar 30

PMID : 20026200






4 Functional Relationships(s)
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1 Enhancing transdermal delivery of insulin using chemical penetration enhancers (CPEs) has several advantages over other non-traditional methods; however, lack of suitable predictive models, make experimentation the only alternative for discovering new CPEs. cpes insulin Homo sapiens
2 To address this limitation, a quantitative structure-property relationship (QSPR) model was developed, for predicting insulin permeation in the presence of CPEs. cpes insulin Homo sapiens
3 Permeation experiments using Franz diffusion cells and resistance experiments were performed to quantify the effect of CPEs on insulin permeability and skin structure, respectively. cpes insulin Homo sapiens
4 The results suggest, molecules with low dipoles that are capable of forming intermolecular bonds with skin lipid bi-layers show promise as effective insulin-specific CPEs. cpes insulin Homo sapiens