Pub. Date : 2010 Mar 30
PMID : 20026200
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Enhancing transdermal delivery of insulin using chemical penetration enhancers (CPEs) has several advantages over other non-traditional methods; however, lack of suitable predictive models, make experimentation the only alternative for discovering new CPEs. | cpes | insulin | Homo sapiens |
2 | To address this limitation, a quantitative structure-property relationship (QSPR) model was developed, for predicting insulin permeation in the presence of CPEs. | cpes | insulin | Homo sapiens |
3 | Permeation experiments using Franz diffusion cells and resistance experiments were performed to quantify the effect of CPEs on insulin permeability and skin structure, respectively. | cpes | insulin | Homo sapiens |
4 | The results suggest, molecules with low dipoles that are capable of forming intermolecular bonds with skin lipid bi-layers show promise as effective insulin-specific CPEs. | cpes | insulin | Homo sapiens |