Title : Impaired interaction between skeletal ryanodine receptors in malignant hyperthermia.

Pub. Date : 2009 Sep

PMID : 20023768






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The MH-triggering volatile anesthetic, halothane, activates RyR1(R615C) and RyR1(WT) to a similar extent, using [(3)H]ryanodine binding as a measure of activation. Halothane ryanodine receptor 1 Homo sapiens
2 The MH-triggering volatile anesthetic, halothane, activates RyR1(R615C) and RyR1(WT) to a similar extent, using [(3)H]ryanodine binding as a measure of activation. Halothane ryanodine receptor 1 Homo sapiens
3 Modeling RyR1 array function with parameters modified to simulate the loss of functional inter-RyR coupling recapitulates the MH molecular phenotype-RyR1 channels leaky to Ca(2+) at rest and long open-times following exposure to halothane. Halothane ryanodine receptor 1 Homo sapiens
4 Modeling RyR1 array function with parameters modified to simulate the loss of functional inter-RyR coupling recapitulates the MH molecular phenotype-RyR1 channels leaky to Ca(2+) at rest and long open-times following exposure to halothane. Halothane ryanodine receptor 1 Homo sapiens
5 Modeling RyR1 array function with parameters modified to simulate the loss of functional inter-RyR coupling recapitulates the MH molecular phenotype-RyR1 channels leaky to Ca(2+) at rest and long open-times following exposure to halothane. Halothane ryanodine receptor 1 Homo sapiens