Pub. Date : 1991 Mar 15
PMID : 2002060
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reversible inhibition of neutrophil elastase by thiol-modified alpha-1 protease inhibitor. | Sulfhydryl Compounds | serpin family A member 1 | Homo sapiens |
| 2 | Whereas native alpha 1-PI combines rapidly and quasi-irreversibly with neutrophil elastase, the thiol-modified alpha 1-PI derivatives are dissociable reversible competitive inhibitors of the enzyme, with values of Ki in the range of 6-7 nM. | Sulfhydryl Compounds | serpin family A member 1 | Homo sapiens |
| 3 | Once native alpha 1-PI has combined with neutrophil elastase, the enzyme-inhibitor complex retains a reactive thiol group, but the two proteins can no longer be dissociated by subsequent reaction with ANM, even after exposure to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. | Sulfhydryl Compounds | serpin family A member 1 | Homo sapiens |