Protein Name serpin family A member 1
Organism Homo sapiens
Gene ID 5265
Gene Symbol


UniProt P01009 (A1AT_HUMAN), E9KL23 (E9KL23_HUMAN)
Relationships Total Number of functionally related compound(s) : 799
Total Number of Articles : 1314

serpin family A member 1

Gene Summary

The protein encoded by this gene is a serine protease inhibitor belonging to the serpin superfamily whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. This protein is produced in the liver, the bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth cells of the gut. Defects in this gene are associated with chronic obstructive pulmonary disease, emphysema, and chronic liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]

  • alpha-1-antitrypsin
  • alpha-1 antitrypsin
  • alpha-1 protease inhibitor
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