Title : Chemotherapeutic drug-induced ABCG2 promoter demethylation as a novel mechanism of acquired multidrug resistance.

Pub. Date : 2009 Dec

PMID : 20019844






1 Functional Relationships(s)
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1 Remarkably, mimicking cytotoxic bolus drug treatment through 12- to 24-hour pulse exposure of ABCG2-silenced leukemia cells, to clinically relevant concentrations of the chemotherapeutic agents daunorubicin and mitoxantrone, resulted in a marked transcriptional up-regulation of ABCG2. Daunorubicin ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens