Title : Activation of spinal alpha-2 adrenoceptors, but not mu-opioid receptors, reduces the intrathecal N-methyl-D-aspartate-induced increase in spinal NR1 subunit phosphorylation and nociceptive behaviors in the rat.

Pub. Date : 2010 Feb 1

PMID : 20007733






2 Functional Relationships(s)
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1 BACKGROUND: A previous study from our laboratories showed that a significant reduction in spinal N-methyl-D-aspartate (NMDA) receptor NR1 subunit phosphorylation (pNR1) is associated with the antiallodynic effect produced by intrathecal (IT) injection of the alpha-2 adrenoceptor agonist, clonidine, in neuropathic rats. Clonidine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus
2 Furthermore, these findings suggest that the modulation of spinal NR1 phosphorylation is linked to the effect of IT clonidine on postsynaptic neuronal activity. Clonidine glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus