Pub. Date : 2010 Jan 15
PMID : 20005707
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase. | Chalcones | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | A novel series of nitrogen-containing chalcones were synthesized by Mannich reaction and were screened for anti-inflammatory related activities such as inhibition of cyclooxygenase-2 (COX-2), trypsin and beta-glucuronidase. | Chalcones | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2. | Chalcones | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Whereas the chalcones with piperidine methyl substitution (8b, 7b, 7c, 6c, 4b, 3c, 3b) were observed as effective inhibitors of COX-2, while the same compounds were found to be less reactive against COX-1 as compared to COX-2. | Chalcones | prostaglandin-endoperoxide synthase 2 | Homo sapiens |