Pub. Date : 2008 Oct
PMID : 19967068
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we found that specific tyrphostin inhibitors of ErbB2 (AG825 and AG879), but not ErbB1 inhibitor (AG1478), suppressed IL-6-induced tyrosine phosphorylation of STAT3 in schwannoma cells. | Tyrphostins | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | Thus, it seems that tyrphostins, which are known as specific inhibitors of the ErbB2 kinase, may have non-specific suppressive effects on the IL-6/STAT3 pathway. | Tyrphostins | signal transducer and activator of transcription 3 | Homo sapiens |