Pub. Date : 2010 Mar
PMID : 19959757
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: Ceramide is now recognized as a negative regulator of insulin signaling by impairing protein kinase B (PKB)/Akt activation. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | OBJECTIVE: Ceramide is now recognized as a negative regulator of insulin signaling by impairing protein kinase B (PKB)/Akt activation. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In different cells, two distinct mechanisms have been proposed to mediate ceramide inhibition of PKB/Akt: one involving atypical protein kinase C zeta (PKCzeta) and the other the protein phosphatase-2 (PP2A). | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | In different cells, two distinct mechanisms have been proposed to mediate ceramide inhibition of PKB/Akt: one involving atypical protein kinase C zeta (PKCzeta) and the other the protein phosphatase-2 (PP2A). | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | RESULTS: Although the PKCzeta-mediated negative effect of ceramide on insulin-stimulated PKB/Akt was dominant in adipocytes, a ceramide action through PP2A outside CEMs, prevented by OKA, was also unraveled. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | CONCLUSIONS: Our results show that ceramide can switch from a PKCzeta-dependent mechanism to a PP2A pathway, acting negatively on PKB/Akt, and hence revealing a critical role of CEMs of the PM in this process. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | CONCLUSIONS: Our results show that ceramide can switch from a PKCzeta-dependent mechanism to a PP2A pathway, acting negatively on PKB/Akt, and hence revealing a critical role of CEMs of the PM in this process. | Ceramides | AKT serine/threonine kinase 1 | Homo sapiens |