PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19959757-1	2010	OBJECTIVE: Ceramide is now recognized as a negative regulator of insulin signaling by impairing protein kinase B (PKB)/Akt activation.	Ceramides	11-19	AKT serine/threonine kinase 1	Homo sapiens	114-117	
19959757-1	2010	OBJECTIVE: Ceramide is now recognized as a negative regulator of insulin signaling by impairing protein kinase B (PKB)/Akt activation.	Ceramides	11-19	AKT serine/threonine kinase 1	Homo sapiens	119-122	
19959757-2	2010	In different cells, two distinct mechanisms have been proposed to mediate ceramide inhibition of PKB/Akt: one involving atypical protein kinase C zeta (PKCzeta) and the other the protein phosphatase-2 (PP2A).	Ceramides	74-82	AKT serine/threonine kinase 1	Homo sapiens	97-100	
19959757-2	2010	In different cells, two distinct mechanisms have been proposed to mediate ceramide inhibition of PKB/Akt: one involving atypical protein kinase C zeta (PKCzeta) and the other the protein phosphatase-2 (PP2A).	Ceramides	74-82	AKT serine/threonine kinase 1	Homo sapiens	101-104	
19959757-5	2010	RESULTS: Although the PKCzeta-mediated negative effect of ceramide on insulin-stimulated PKB/Akt was dominant in adipocytes, a ceramide action through PP2A outside CEMs, prevented by OKA, was also unraveled.	Ceramides	58-66	AKT serine/threonine kinase 1	Homo sapiens	70-96	
19959757-8	2010	CONCLUSIONS: Our results show that ceramide can switch from a PKCzeta-dependent mechanism to a PP2A pathway, acting negatively on PKB/Akt, and hence revealing a critical role of CEMs of the PM in this process.	Ceramides	35-43	AKT serine/threonine kinase 1	Homo sapiens	130-133	
19959757-8	2010	CONCLUSIONS: Our results show that ceramide can switch from a PKCzeta-dependent mechanism to a PP2A pathway, acting negatively on PKB/Akt, and hence revealing a critical role of CEMs of the PM in this process.	Ceramides	35-43	AKT serine/threonine kinase 1	Homo sapiens	134-137