Title : Estradiol or genistein prevent Alzheimer's disease-associated inflammation correlating with an increase PPAR gamma expression in cultured astrocytes.

Pub. Date : 2010 Feb 2

PMID : 19948157






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1 Astrocytes were pretreated with 17-beta estradiol or with genistein, and 48 h later treated with 5 microM amyloid beta (A beta) for 24 h. We found that A beta induces inflammatory mediators, such as cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha). Genistein amyloid beta precursor protein Homo sapiens