Pub. Date : 2010 Jan
PMID : 19947891
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This article reviews the pharmacokinetic differences between fexofenadine enantiomers in humans and summarizes the previous reports that co-administration of P-glycoprotein inhibitors has altered the stereoselective pharmacokinetics of fexofenadine enantiomers. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | This article reviews the pharmacokinetic differences between fexofenadine enantiomers in humans and summarizes the previous reports that co-administration of P-glycoprotein inhibitors has altered the stereoselective pharmacokinetics of fexofenadine enantiomers. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Co-administration of itraconazole and/or verapamil significantly increased the AUC(0 - 24) of both enantiomers; their influence on the P-glycoprotein-mediated transport of (S)-fexofenadine was greater than that of the (R)-enantiomer. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | However, because t(max) and t(1/2) were constant in both studies, the fexofenadine stereoselective pharmacokinetics appears to be due to P-glycoprotein efflux activity in the small intestine, which suggests that P-glycoprotein probably possesses the chiral discriminatory abilities. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | However, because t(max) and t(1/2) were constant in both studies, the fexofenadine stereoselective pharmacokinetics appears to be due to P-glycoprotein efflux activity in the small intestine, which suggests that P-glycoprotein probably possesses the chiral discriminatory abilities. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |