Title : Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARalpha.

Pub. Date : 2010 Feb

PMID : 19938896






3 Functional Relationships(s)
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1 First, we show that MEHP induces a dose-dependent release of the pro-inflammatory tumour necrosis factor-alpha (TNF-alpha) in AMs, giving a maximal (5-fold) increase at 0.7 mM. mono-(2-ethylhexyl)phthalate tumor necrosis factor Rattus norvegicus
2 Further, we found that the 5-LO inhibitor nordihydrogualaretic acid (NDGA) significantly reduced both MEHP-induced TNF-alpha release and MEHP-induced formation of reactive oxygen species (ROS), supporting an involvement of the 5-LO pathway in MEHP induced inflammatory reactions. mono-(2-ethylhexyl)phthalate tumor necrosis factor Rattus norvegicus
3 Last, we found that MK-886, a known inhibitor of peroxisome proliferator-activated receptor alpha (PPARalpha), increased the MEHP-induced TNF-alpha response. mono-(2-ethylhexyl)phthalate tumor necrosis factor Rattus norvegicus