Title : Phosphodiesterase 3 inhibition reduces platelet activation and monocyte tissue factor expression in knee arthroplasty patients.

Pub. Date : 2009 Dec

PMID : 19934866






3 Functional Relationships(s)
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1 Furthermore, perioperative tissue factor expression on monocytes and fibrin monomer complex production were reduced by milrinone infusion in patients undergoing total knee arthroplasty. Milrinone coagulation factor III, tissue factor Homo sapiens
2 In vitro studies using adenosine diphosphate- and collagen-stimulated blood samples from healthy volunteers confirmed the antiplatelet effects and reduced monocyte tissue factor expression by milrinone. Milrinone coagulation factor III, tissue factor Homo sapiens
3 CONCLUSION: Continuous milrinone infusion has the potential to reduce platelet activation and monocyte tissue factor expression during the perioperative period in total knee arthroplasty. Milrinone coagulation factor III, tissue factor Homo sapiens