Pub. Date : 2010 Feb 15
PMID : 19931604
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Relations between strain and gender dependencies of irinotecan toxicity and UGT1A1, CES2 and TOP1 expressions in mice. | Irinotecan | UDP glucuronosyltransferase 1 family, polypeptide A1 | Mus musculus |
| 2 | CPT-11 is bio-activated through CES, detoxified through UGT1A1 and inhibits TOP1. | Irinotecan | UDP glucuronosyltransferase 1 family, polypeptide A1 | Mus musculus |
| 3 | Genetic background and gender significantly altered the molecular prediction of irinotecan toxicity by UGT1A1, CES2 and TOP1 mRNA expressions. | Irinotecan | UDP glucuronosyltransferase 1 family, polypeptide A1 | Mus musculus |