Title : Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Pub. Date : 2010 Feb 15

PMID : 19931552






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Arsenite promotes centrosome abnormalities under a p53 compromised status induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). arsenite tumor protein p53 Homo sapiens
2 NNK treatment could also reduce arsenite-induced G2/M cell cycle arrest and apoptosis, these cellular effects were found to be correlated with p53 dysfunction. arsenite tumor protein p53 Homo sapiens
3 Arsenite would act specifically on this p53 compromised status to induce centrosomal abnormality and colony formation. arsenite tumor protein p53 Homo sapiens