Title : Analysis of CYP3A4-HIV-1 protease drugs interactions by computational methods for Highly Active Antiretroviral Therapy in HIV/AIDS.

Pub. Date : 2010 Jan

PMID : 19931478






1 Functional Relationships(s)
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1 We have shown that HIV-1 protease drugs such as tipranavir, nelfinavir, lopinavir, and atazanavir differ in their binding modes on each other for metabolic clearance in CYP3A4, whereas ritonavir, amprenavir, indinavir, saquinavir, fosamprenavir, and darunavir share the same binding mode. Lopinavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens