Title : AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers.

Pub. Date : 2010 Feb

PMID : 19925783






4 Functional Relationships(s)
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1 AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers. Phospholipids cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 In this study, atomic force microscopy was applied to characterise the association of CYP2C9 to dimyristoylphosphatidylcholine (DMPC) supported phospholipid bilayers. Phospholipids cytochrome P450 family 2 subfamily C member 9 Homo sapiens
3 Despite lacking the N-terminus transmembrane spanning domain, the CYP2C9 protein appeared to partially embed into the membrane bilayer, as evidenced by an increase in melting temperature of surrounding phospholipids. Phospholipids cytochrome P450 family 2 subfamily C member 9 Homo sapiens
4 Reversible binding of CYP2C9 via an engineered His tag to a phospholipid bilayer was facilitated using nickel-chelating lipids, presenting potential applications for biosensor technologies. Phospholipids cytochrome P450 family 2 subfamily C member 9 Homo sapiens