Pub. Date : 2010 Jan
PMID : 19924122
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oral administration of the taxanes docetaxel and paclitaxel is hampered by their affinity for drug transporters, especially ABCB1 (P-glycoprotein, Pgp); extensive first-pass metabolism by cytochrome P450 3A (CYP3A); and poor drug solubility. | Paclitaxel | ATP-binding cassette, sub-family B (MDR/TAP), member 1B | Mus musculus |